Shanghai Zerun Biological Technology Co., Ltd. is a national major new drug creation project undertaker, Shanghai Postdoctoral Research Station, and Shanghai High-tech Enterprise. It is a subsidiary of Watson Biological. It has a recombinant virus-like particle (Virus Like-Particle, VLP for short) preparation technology platform, a recombinant protein expression technology platform, an innovative adjuvant evaluation platform and an inactivated virus vaccine research and development technology platform. The self-developed recombinant human papillomavirus bivalent (Human papillomavirus (HPV), type 16/18) vaccine has been approved by the State Food and Drug Administration for drug clinical trials. It is in the second clinical research phase and is the first domestic company to enter HPV vaccine expressed in eukaryotic cells at the clinical stage. The therapeutic HPV vaccine of Zerun Anke, a subsidiary of Zerun Biological Holdings, has applied for category 1 clinical trials of therapeutic biological products and has been formally accepted. Zerun Biotech also has a number of new recombinant vaccines based on the VLP platform in the preclinical research stage. Zerun Biotechnology has dozens of domestic and foreign invention patent applications or patent authorizations in preventive HPV vaccines, therapeutic HPV vaccines, and hepatitis A vaccines.

Shanghai Zerun Biotech uses Shanghai Jingxin Technology's fully automatic sample rapid grinder to break the cultured yeast. Through Shanghai Jingxin Technology's fully automatic sample rapid grinder, 96 samples can be processed at a time in a short time without cross-contamination. Compared with the previous ultrasonic wall breaking and high-pressure wall breaking in the laboratory, the yield rate is greatly improved, and Free up a lot of labor.

There is no significant difference in the concentration and purity of the DNA and RNA extracted from FT after the automatic sample rapid grinder treatment and manual liquid nitrogen grinding treatment of Shanghai Jingxin (pairwise test P>0.05). However, manual grinding has a larger sample loss rate. For samples with low DNA extraction concentration, the automatic grinder can achieve zero sample loss. It has obvious advantages in DNA extraction, and the manual processing process is complicated and easy to cross. Contamination, operation time and other aspects are not as good as Shanghai Jingxin's automatic sample rapid grinder, so the automatic grinder has great advantages for DNA extraction compared to manual grinding.